| Identification |
|---|
| HMDB Protein ID
| CDBP03293 |
| Secondary Accession Numbers
| Not Available |
| Name
| Short transient receptor potential channel 7 |
| Description
| Not Available |
| Synonyms
|
- TRP-7
- Transient receptor protein 7
- TrpC7
- hTRP7
|
| Gene Name
| TRPC7 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| ion channel activity |
| cation channel activity |
| calcium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| Process |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
| calcium ion transport |
| establishment of localization |
| transport |
| transmembrane transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31.1 |
| SNPs
| TRPC7 |
| Gene Sequence
|
>2589 bp
ATGTTGAGGAACAGCACCTTCAAAAACATGCAGCGCCGGCACACAACGCTGAGGGAGAAG
GGCCGTCGCCAGGCCATCCGGGGTCCCGCCTACATGTTCAACGAGAAGGGCACCAGTCTG
ACGCCCGAGGAGGAGCGCTTCCTGGACTCGGCTGAGTATGGCAACATCCCGGTGGTCCGG
AAAATGCTGGAGGAGTCCAAGACCCTTAACTTCAACTGTGTGGACTACATGGGGCAGAAC
GCTCTGCAGCTGGCCGTGGGCAACGAGCACCTAGAGGTCACGGAGCTGCTGCTGAAGAAG
GAGAACCTGGCACGGGTGGGGGACGCGCTGCTGCTGGCCATCAGCAAGGGCTATGTGCGC
ATCGTGGAGGCCATCCTCAACCACCCGGCCTTCGCGCAGGGCCAGCGCCTGACGCTCAGC
CCGCTGGAACAGGAGCTGCGCGACGACGACTTCTATGCCTACGACGAGGACGGCACGCGC
TTCTCCCACGACATCACGCCCATCATCCTGGCGGCGCACTGCCAGGAGTATGAGATCGTG
CACATCCTGCTGCTCAAGGGCGCCCGCATCGAGCGGCCCCACGACTACTTCTGCAAGTGC
AATGAGTGCACCGAGAAACAGCGGAAAGACTCCTTCAGCCACTCGCGCTCGCGCATGAAC
GCCTACAAAGGACTGGCGAGTGCTGCCTACTTGTCCCTGTCCAGCGAAGACCCTGTCCTC
ACCGCCCTGGAGCTCAGCAACGAGTTAGCCAGACTAGCCAACATTGAGACTGAATTTAAG
AACGATTACAGGAAGTTATCTATGCAATGCAAGGATTTTGTAGTGGGCGTGCTGGACCTG
TGCCGAGACACAGAAGAGGTGGAAGCAATTTTAAACGGTGATGTGAACTTCCAAGTCTGG
TCCGACCACCACCGTCCAAGTCTGAGCCGGATCAAACTCGCCATTAAATATGAAGTCAAG
AAGTTCGTTGCTCATCCTAACTGTCAGCAGCAATTGCTTACCATGTGGTATGAAAATCTC
TCAGGCTTACGTCAACAGTCTATCGCTGTGAAATTCCTGGCTGTCTTTGGAGTCTCCATA
GGCCTCCCTTTTCTCGCCATAGCCTATTGGATTGCTCCGTGCAGCAAGCTAGGACGAACC
CTGAGGAGCCCTTTCATGAAGTTTGTAGCTCATGCAGTTTCTTTTACAATCTTCTTGGGA
TTATTAGTTGTGAATGCATCTGACCGATTTGAAGGTGTTAAAACCCTGCCAAACGAAACC
TTCACAGACTACCCAAAACAAATCTTCAGAGTGAAAACCACACAGTTCTCCTGGACAGAA
ATGCTCATTATGAAGTGGGTCTTAGGAATGATTTGGTCCGAATGCAAGGAAATCTGGGAG
GAGGGGCCACGGGAGTACGTGCTGCACTTGTGGAACCTGCTAGATTTCGGGATGCTGTCC
ATCTTCGTGGCCTCCTTCACAGCACGCTTCATGGCCTTCCTGAAGGCCACGGAGGCACAG
CTGTACGTGGACCAGCACGTGCAGGACGACACGCTGCACAATGTCTCGCTTCCGCCGGAA
GTGGCATACTTCACCTACGCCAGGGACAAGTGGTGGCCTTCAGACCCTCAGATCATATCG
GAAGGGCTCTACGCGATAGCCGTCGTGCTGAGCTTCTCTCGCATTGCATACATTCTGCCA
GCCAACGAGAGTTTTGGGCCCCTGCAGATCTCGCTAGGGAGAACTGTGAAAGATATCTTC
AAGTTCATGGTCATTTTCATCATGGTATTTGTGGCCTTCATGATTGGGATGTTCAACCTG
TACTCTTACTACCGAGGTGCCAAATACAACCCAGCGTTTACAACGGTTGAAGAAAGTTTT
AAAACTTTGTTTTGGTCCATATTCGGCTTATCTGAAGTAATCTCAGTGGTGCTGAAATAC
GACCACAAATTCATCGAGAACATTGGCTACGTTCTCTACGGCGTTTATAACGTCACCATG
GTGGTAGTGTTGCTCAACATGCTAATAGCCATGATAAACAACTCCTATCAGGAAATTGAG
GAGGATGCAGATGTGGAATGGAAGTTCGCCCGAGCAAAACTCTGGCTGTCTTACTTTGAT
GAAGGAAGAACTCTACCTGCTCCTTTTAATCTAGTGCCAAGTCCTAAATCATTTTATTAT
CTCATAATGAGAATCAAGATGTGCCTCATAAAACTCTGCAAATCTAAGGCCAAAAGCTGT
GAAAATGACCTTGAAATGGGCATGCTGAATTCCAAATTCAAGAAGACTCGCTACCAGGCT
GGCATGAGGAATTCTGAAAATCTGACAGCAAATAACACTTTGAGCAAGCCCACCAGATAC
CAGAAAATCATGAAACGGCTCATAAAAAGATACGTCCTGAAAGCCCAGGTGGACAGAGAA
AATGACGAAGTCAATGAAGGCGAGCTGAAGGAAATCAAGCAAGATATCTCCAGCCTGCGC
TATGAGCTTCTTGAGGAAAAATCTCAAGCTACTGGTGAGCTGGCAGACCTGATTCAACAA
CTCAGCGAGAAGTTTGGAAAGAACTTAAACAAAGACCACCTGAGGGTGAACAAGGGCAAA
GACATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 862 |
| Molecular Weight
| 99561.3 |
| Theoretical pI
| 7.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["352-372", "384-404", "466-486", "538-558", "582-602", "652-672"]
|
| Protein Sequence
|
>Short transient receptor potential channel 7
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVR
KMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVR
IVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIV
HILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVL
TALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVW
SDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSI
GLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNET
FTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLS
IFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIIS
EGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNL
YSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTM
VVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYY
LIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRY
QKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQ
LSEKFGKNLNKDHLRVNKGKDI
|
| External Links |
|---|
| GenBank ID Protein
| 9798452 |
| UniProtKB/Swiss-Prot ID
| Q9HCX4 |
| UniProtKB/Swiss-Prot Entry Name
| TRPC7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ272034 |
| GeneCard ID
| TRPC7 |
| GenAtlas ID
| TRPC7 |
| HGNC ID
| HGNC:20754 |
| References |
|---|
| General References
| Not Available |