| Identification |
|---|
| HMDB Protein ID
| CDBP00972 |
| Secondary Accession Numbers
| Not Available |
| Name
| Arginase-2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Kidney-type arginase
- Non-hepatic arginase
- Type II arginase
|
| Gene Name
| ARG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in arginase activity |
| Specific Function
| May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
|
| GO Classification
|
| Biological Process |
| cellular response to interferon-gamma |
| negative regulation of nitric-oxide synthase activity |
| negative regulation of striated muscle contraction |
| cellular response to lipopolysaccharide |
| nitric oxide biosynthetic process |
| response to glucose stimulus |
| regulation of nitric oxide biosynthetic process |
| lung development |
| response to mercury ion |
| response to selenium ion |
| midgut development |
| ureteric bud development |
| cellular response to dexamethasone stimulus |
| maternal process involved in female pregnancy |
| regulation of L-arginine import |
| response to amine stimulus |
| response to axon injury |
| response to hypoxia |
| response to cadmium ion |
| response to herbicide |
| striated muscle contraction |
| response to vitamin E |
| response to amino acid stimulus |
| urea cycle |
| apoptotic process |
| arginine metabolic process |
| response to drug |
| Cellular Component |
| mitochondrial matrix |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| arginase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| Molecular Function |
| metal ion binding |
| arginase activity |
| Process |
| metabolic process |
| arginine metabolic process |
| cellular metabolic process |
| glutamine family amino acid metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amoebiasis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24.1 |
| SNPs
| ARG2 |
| Gene Sequence
|
>1065 bp
ATGTCCCTAAGGGGCAGCCTCTCGCGTCTCCTCCAGACGCGAGTGCATTCCATCCTGAAG
AAATCCGTCCACTCCGTGGCTGTGATAGGAGCCCCGTTCTCACAAGGGCAGAAAAGAAAA
GGAGTGGAGCATGGTCCCGCTGCCATAAGAGAAGCTGGCTTGATGAAAAGGCTCTCCAGT
TTGGGCTGCCACCTAAAAGACTTTGGAGATTTGAGTTTTACTCCAGTCCCCAAAGATGAT
CTCTACAACAACCTGATAGTGAATCCACGCTCAGTGGGTCTTGCCAACCAGGAACTGGCT
GAGGTGGTTAGCAGAGCTGTGTCAGATGGCTACAGCTGTGTCACACTGGGAGGAGACCAC
AGCCTGGCAATCGGTACCATTAGTGGCCATGCCCGACACTGCCCAGACCTTTGTGTTGTC
TGGGTTGATGCCCATGCTGACATCAACACACCCCTTACCACTTCATCAGGAAATCTCCAT
GGACAGCCAGTTTCATTTCTCCTCAGAGAACTACAGGATAAGGTACCACAACTCCCAGGA
TTTTCCTGGATCAAACCTTGTATCTCTTCTGCAAGTATTGTGTATATTGGTCTGAGAGAC
GTGGACCCTCCTGAACATTTTATTTTAAAGAACTATGATATCCAGTATTTTTCCATGAGA
GATATTGATCGACTTGGTATCCAGAAGGTCATGGAACGAACATTTGATCTGCTGATTGGC
AAGAGACAAAGACCAATCCATTTGAGTTTTGATATTGATGCATTTGACCCTACACTGGCT
CCAGCCACAGGAACTCCTGTTGTCGGGGGACTAACCTATCGAGAAGGCATGTATATTGCT
GAGGAAATACACAATACAGGGTTGCTATCAGCACTGGATCTTGTTGAAGTCAATCCTCAG
TTGGCCACCTCAGAGGAAGAGGCGAAGACTACAGCTAACCTGGCAGTAGATGTGATTGCT
TCAAGCTTTGGTCAGACAAGAGAAGGAGGGCATATTGTCTATGACCAACTTCCTACTCCC
AGTTCACCAGATGAATCAGAAAATCAAGCACGTGTGAGAATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 38577.515 |
| Theoretical pI
| 6.468 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arginase-2, mitochondrial
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS
LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH
SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ
LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
|
| External Links |
|---|
| GenBank ID Protein
| 189065548 |
| UniProtKB/Swiss-Prot ID
| P78540 |
| UniProtKB/Swiss-Prot Entry Name
| ARGI2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK312484 |
| GeneCard ID
| ARG2 |
| GenAtlas ID
| ARG2 |
| HGNC ID
| HGNC:664 |
| References |
|---|
| General References
| Not Available |